Personally, I'd rather use the Cthulhu ruleset for stuff that's not so forcibly Lovecraftian. Anyone seen that new Miracles show on ABC Monday nights? That's the kind of stuff I'd like to use the CoC rulebook for, and it's not really "Cthulhoid" at all in tone. But those three folks could almost be an iconic CoC investigator party, and those set-ups are just as eerie and creepy as anything Lovecraft ever wrote, if not moreso. In fact, I find Lovecraftian "horror" to not be really horrible: it's just too odd to really scare me or touch any primal nerves.
Anyway, there's my little gripe about Cthulhu -- I'd like to see the rules used for other types of horror games, not just reprints of old CoC stuff based on actual Lovecraft novellas. Although The Case of Charles Dexter Ward would make a good set-up: much more the kind of stuff I like than At the Mountains of Madness.