Bonus to Will saves? Iron Will as bonus feat? Something else?Great wyrms, because of their innate egotism and strength of will, cannot ever be subdued; attacking one in this manner is a grave mistake.
That's one thing we won't have to worry about.Wyrms cannot cast magic.
This should prove difficult, since there are no "called shots". Just brainstorming here, but maybe something to the effect of: "If a critical hit with a slashing or piercing weapon is confirmed on a great wyrm, the weapon's damage mulitplier is increased by 1. Thus, a longsword deals x3 damage, while a scythe would deal x5."Because great wyrms are so old, each one has at least one especially vulnerable spot upon its body. The dragon’s scaly hide will have been damaged by disease, combat, or by general wear and tear at these points, and nervous ganglia tend to gather there. During physical combat, a person striking at a great wyrm with a sharp-edged weapon (including arrows and hurled hand axes and daggers) has a 1% chance of accidentally hitting such a vulnerable spot. The blow will strike the dragon as if against AC 4, and the blow will do double damage to the wyrm. The wyrm will immediately retreat if struck in such a spot, and will attempt to find safety and recover from the wound. Magical attacks, even magic missiles, will not affect the wyrm in this way. If a vulnerable spot is located and recognized, attackers may strike at the spot further unless the wyrm covers the spot or moves it out of reach of weapons.

(Dungeons & Dragons)
Rulebook featuring "high magic" options, including a host of new spells.