I agree that Journey's Home isn't the most natural choice for Nilasa's murder, but I went with it for a few reasons. I really wanted to focus on the effects of the houses for this campaign, and their actions tracing all the way back to the War of the Mark. A Cannith enclave would be the first choice, but my players a quite savvy, and the moment they hear "Big construction going on and having to do with House Cannith", they're going to immediately think Warforged Colossus. Plus, the campaign that was run in Sharn focused a lot on Cannith South and Merrix d'Cannith, and I didn't want to retread that ground so soon. Not that I neglect them entirely.
Additionally, I wanted to give House Orien a good shake, as we are in the heart of the House. So the notes that Nilasa stole from Baron Kwanti show large amounts of high value and magical resources struck from cargo manifests, deeds of facilities and industrial factories hidden behind enough ownerships to throw off any ties to Orien, and all covered by independent Brelish owners, seemingly unrelated. Even some supplies acquired from Cannith South with promises of more on the way. All in all suspicious, but not damning by itself.
In this campaign, House Orien is quickly overtaking the fractured House Cannith as the largest house, thanks in no small part to acquiring a way to cross the Mournland in a lightning rail (thanks to the events of the previous campaign), convincing Thrane to rebuild the White Bridge connecting Thaliost and Rekkenmark, and House Cannith being in scandal and shambles, with Merrix d'Cannith even having disappeared after his illegal warforged were discovered. Will likely have him join the Ob.