I see a potential conflict between the coherence or "orthodxy" with the old canon and the necessary creative freedom. Some players want to be loyal to the old canon, but others would rather to can customize in their way, for example adding martial adepts as gladiators in the arena, totemist shamans (magic of incarnum) who worship Lovecraftian kaijus, sorcerers who cast primal magic, vestige binders and shadowcasters (3.5 Tome of Magic), or psionic "ardents" (a new class from 3.5 The complete psionic. Why not dromites, elans, maenads, xephs or syands (PC races from 3.5) in Dark Sun? Minotaurs, "drays" and tielflings were possible in 4th. even the shadar-kai. If you want there is a crossover with Jackandor thanks special planar gate.
In your tabletop you choose the type of religion in your DS game: deism, animism, cult to the leader, worship of the ancestors, or the nature spirits..
And even if an official DS setting is published again, the metaplot, if this is not rebooted, will be frozen for more years, with the rest of no-FR settings, and what a pity, because I would like to know the fate of Kalidnay