Knowning Canon, and being a slave to it, are two very different things. Didn't anyone else just ignore all the big name FR NPCs and novel plots?
I basically just dug into the boxed set(s) and books (Like The Savage Frontier) and used all the baddies like The Zhentarim, Church of Cyric, Xvim/Bane, Myrkul, Bhaal, etc and ignored the specific NPCs (The Fzouls & Manshoons for example) and did the same for the Good aligned orgs- Elminster, the Chosen, Drizzt, or Khelben never had any air time at all, yet the PCs could find themselves working with/for The Harpers, or the Church of (insert "good" deity" here) through low level "no name" NPCs and adventures of my own creation. The charcaters were thrust into the world like anyone- having a POV that is based on where they grew up, and what they have heard about far away places and people could be VERY different in actuality. Harpers were not know by every farmer and villager in the relams, though they may know of a good natured (pick a class) who has proven helpful to the town in times of need. Those types of groups are TOTALLY behind the scenes. while The Zhents may be well known, but the PCs are not likely to know anything about them other than the obvious an ordinary citizen under thier oppression would know (they control all trade, many are allied with a foul church and you'll be dead if you cross them or pry). While the Cleric of Sune may have some idea of what the other major faiths are about, they do not know the all the details of the Avatar Trilogy and Lord Ao, and the Chosen, and all the other "Godswar" stuff.
Maybe I'm weird, but to me FR is an absolutely fantastic setting if you just keep the idea of "The PCs are the heroes of the world" at the forefront of everything you do as the DM (this proves correct for ANY game or game world). As a player, I'd have strangled a DM if they merely were following along with the TSR Novel Division and weaving my "pawn" into the cracks of the setting. Lame.