Wow! I feel so important now.
Anyways, as far as the Red Wizards are concerned, I think the 3E developments really neutered them as a villain group. The enclaves were an interesting concept, and they did a good job of explaining the ease with which one could buy and sell magic items in 3E, but the whole thing made the Red Wizards seem much less sinister and mysterious.
One should remember that they specifically mentioned the enclave Red Wizards are still around. They aren't affiliated with the nation, Thay, anymore, and in fact they're now even more useful and interesting as villains and allies as they still (presumably) do what they did in 3E, but now you have all sorts of potential for stuff like the various European governments-in-exile that existed during WW2 and expatriates with nothing left to lose.
Just as the design goals for Eberron (when it won the setting contest) were that the setting had to be able to include everything that was part of D&D, FR now has to include everything that is part of 4E. So since the game designers created a new version of the Dragonborn race, the FR setting team now had to justify a way to make it fit in FR.
To be fair, this was always a design goal of the Forgotten Realms. It was very explicit during the 2E era that anything in D&D could be in or accessed from the Realms.
And the comment that "If you are an old player, all that stuff on your shelf is still pertinent" made me chuckle. In the start of the podcast they talk about how everything is changed, brand new and mysterious ... then claim that the stuff on your shelf is pertinent.
It wasn't ret-conned out of existence. There is at least one functioning Time Portal in the Realms circa 4E. Everything that happened in previous editions still happened and still laid the foundation for the 4E world. Therefor, all that stuff on your shelf
is still pertinent.
The implied setting is PoL, and let's not forget FR. My assumption is that the "shoe horn" comment was made in answer to the worries that WotC would force PoL on every setting, just as it did to FR.
"Shoe horn" was my words, and the comment I was paraphrasing was in regards to FR. They said (I'm paraphrasing from memory) that they didn't set out to force the Realms into a PoL dynamic. They noted how the Realms was characterized by a number of large, ancient, civilized and interconnected regions. They wanted to reduce this somewhat, but they didn't set out to totally clean the slate and make the setting PoL, just a little bit more PoL. From what we've heard, I feel that they were successful in this goal.