Yes, my campaign features two homebrewed base classes, the elementalist and the cannabix.
Elementalists channel elemental forces, and their spells sometimes do nonlethal damage to them.
Cannabix are cannibalistic chaotic ability-increasing nature-fearing semi-druidic guys.
I'm currently also running a heavily modified, low-magic campaign as well; that one has tweaks to most of the base classes and replaces clerics and paladins with priests and knights.