Our first full 4e game with all the rules occurred yesterday; on the whole, the players had a good time, but one player definitely has issues with the game -- he's only ever played 3e, and prefers wizards, so the deck is definitely stacked against him as to liking this game.
We had approx. 6 1/2 hours of play, which saw 4 combat encounters, a skill challenge, and some roleplay as to the beginnings of the party, and some of the exploration of an ancient Dhaakani holy shrine. The players are still getting used to their abilities, and we're relearning a few things, that are different from when we playested 4e, and we're having to clear those rules out of our heads and make sure we're using the real rules.
I noticed the first strands of tactics and teamwork taking shape at the last combat, as people were helping one another out more, and they were starting to get the hang of their abilities.
We still plan to keep playing for a while, but we're doing it biweekly to give the players who don't like it as well as 3e some time with their preferred system, too.