Obviously Gencon is still immensly popular.  Even with the threat of plague looming over the horizon, hordes of gamers are willing to descend upon it for a few days of gaming.  Gencon was a place where you could go and interact with people in the industry, get a look at new products from both large and smaller publishers, buy things from vendors that aren't available in your area, do a little gaming, and of course there all panels.  But it's not 1990 any more.  Thanks to the internet, this very site for example, I don't have to go to Gencon for any of that.  I don't need to go to Gencon to hear about the latest in gaming news, to find vendors selling stuff I can't find in my area, or even to hear about games from smaller publishers. 
How relevant are large cons to do business for game companies?  And will they remain relevant?