You don't have to nuke the campaign, you can just throw a Molotov cocktail or two. The PCs fail their mission, lose the treasure, whatever.because in reality, you can't.
players will take a long rest when they feel they want a long rest. period.
What will you do nuke the campaign? sure, you can, but what will that get you?
If you always put the stakes up to maximum, then you can't afford to ever let the PCs fail. Players who want to take advantage of that can do so in quite a few ways.