As a married guy, I worked things out with my wife. I run a regular game on Wednesdays (when she works late), and 1/month on Sundays. I like to spend time with her, and vice-versa, even if it's only hanging out on the couch and watching TV... That's at least as important as gaming in my life.
I don't think the unmarried folks on the board (*cough* justanobody *cough*) realize that marriage involves actually living with someone, matching your schedules, and making your lives work together. Gaming is important, but so is everything else in your life... Homes take work. Marriages take work. Pets take work. Kids take more work than all the rest of those combined, and when my wife and I have one, I expect gaming will take a back seat for some time.
With that said, joe, the rest of your group should not be beholden to his schedule. Make game night on a night when the most players can show up, and set the schedule. If this guy can make it, great. If not, find another player (if possible). You shouldn't spoil your game for one guy. Even more to the point, don't blame his wife. He's a grown-up, and it's his job to work things out, not yours. From his perspective, your game is far less important than his life.
-O