In my current campaign, now running on for some 15 months (with the player characters at about that level), the world is being invaded by unseelie fey, portaling into the world at random, Mortal Kombat style.
It all began when the bright-eyed and bushy-tailed 1st level PCs made an enemy of Randall Jakobin, an evil sorcerer who also happens to be the guildmaster of the assassins' guild in Pensula City. Randall had a plot to summon up some devils to be his allies; but the PCs showed up with a phlogiston bomb (read, the steampunk equivalent of a tac-nuke) that they had obtained from Jack Orestes, the guildmaster of a true neutral aligned thieves' guild which is an enemy to Randall's guild. Long story short, they saw Randall cast a spell to try and
gate in some fiends, but before he could finish, they kicked him through the portal (effectively sending him to hell), and then they threw the bomb in (effectively nuking Randall, along with a significant portion of hell... not that that was the last they'd see of this villain, of course).
Problem is, they went and used high technology to counter high magic. There was a freaky-deaky reaction and the gate shifted from Baator to the plate of nightmares, and out stepped a tall fey woman who dropped the Gozer line ("Are you gods?") and then vanished. (The PCs didn't know it, but the woman was Morgan le Fey, queen of evil fey.) Thereafter, they went into the city and discovered that lanky hobgoblins with dragonfly wings were appearing out of portals everywhere and tearing up the city, and gremlins had overrun the airship field, causing all sorts of mayhem with every kind of technology. Ever since then, the whole continent has been going to hell in a handbasket, with evil fey popping up everywhere: pookas disguised as little children running through the streets and cursing people; redcaps on the highways going serial killer on all the random passers-by; nockers haunting mines and dungeons, and driving the kobolds and goblins up onto the surface in desperation (where they, in turn, have to rob and pillage to survive); and a fey troll under every bridge!
That's my campagin. I'm guessing the PCs are going to be 25th level or so before they can take on Morgan herself and end the invasion, as well as the pure *chaos* that the world has become.