If you are afflicted lycanthrope, lycanthropy is a curse. But if you are a natural lycanthrope, wouldn't it be a different story?
Anyhow, the next best thing is being the descendant of a lycanthrope. D&D has the Shifters. Level Up otoh has the Garoul.
a5e.tools
The legends and sources of lycanthropy are famous throughout many civilizations, but less well-known are the garoul. Descended long ago from the children of werewolves, these lupine folk are free to embrace their wolfish nature without fear of losing control, making many good neighbors, fierce friends, and even fiercer enemies. This common lineage aside, they are as varied as any heritage: travelers in obscuring cloaks pull up in their covered wagon, their eyes glowing from the shadows; a furry child with pointed canines knocks at the door, offering a freshly picked pumpkin as a gift; lupine figures gather on a remote, starlit hill, lifting their hands to worship the moon. Each of these people are the garoul.
The garoul are wolf-folk of lycanthropic heritage, gifted with deft hunting instincts and a deep connection to the wilds. Werewolves transform between a variety of forms, and this shows up for the garoul by way of physical diversity. Most garoul resemble bipedal wolves, harkening back to their ancestors’ hybrid form. Other garoul present more on the humanoid side of their lineage, and would be able to pass as humans and elves if it weren’t for certain distinctive lupine features, such as yellow eyes or sharp canines.
Garoul tap into their bestial ancestry to enhance their strength, but how they do so varies. Some garoul are intimately connected to their lupine instincts at all times, while others focus this connection to physically turn into wolves.
I hope A5e eventually comes up with heritages that cover the other kinds of lycanthropy.