As others have commented, if it's a guy portraying a female PC as wanton, or seducing other characters or things like that, then yeah, it can be a bit uncomfortable. But I really haven't run into scenarios like that.
Banshee
Actually, I DID do something like both of those.
My HERO PC- Hazard- was a 7' alien gladiatrix who had won her freedom and was now "retired" to the comfy backwater Earth...and she thought the gadgeteer in the power-armor suit was cute as hell. Her species was one in which the females were much bigger than the males (like many species on Earth), so she had a reverse-chauvinistic view of human males...but HIS PC had proven himself worthy of her attention.
Think of the relationship of Whorf & Dax through the looking glass with a dash of Moonlighting and/or Cheers and you're on the right track.
They never did anything- she was aware that humans were too...fragile...for her attention- but their interplay was hilarious for...well...at least the two of us.
(FWIW, both PCs were played by straight males.)
In a GURPS Cyberpunk campaign, I played a female "Street Samurai" who was 1 part Elric of Melnibone and one part biker-chick slut (based on someone I knew personally). Because of her cybernetic enhancements, she felt safe anywhere, so chased men like some men chase women. That, coupled with her Harley and black Monofilament Vibra-Sword made her a LOT of fun. The only men she actually seduced, though, were NPCs.
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