Video games are a great source of inspiration for D&D. Especially if you take some game tropes, like being chased by the giant monster, and make them encounters. Trying to flee the giant monster while tunnels collapse and bridges snap is great fun. I've had an itch to run a boss D&D encounter like the God of War battle where you take on Chronus. Use something huge like a dragon and have the party end up on top of it when it happens to take flight. Have them battling it while trying to stay on and get it to crash land somewhere safe for them. Make the entire encounter a mix of skills, wits and combat rather that have the PC just shoot some arrows until the dragon lands so they can melee it. Chronus was so huge in God of War that he was the entire level. Putting the PCs in that kind of situation on that scale would be a blast. I've used game sub quest ideas, monster encounters and even some NPCs from video games. Take inspiration for anything and everything. I ran an undead themed campaign that I based very heavily on The Walking Dead and a bunch of zombie survival games. Unfortunately it got a little too scary for the PCs and we switched to something else. That was a real shame, as I was just about to get to The Governor inspired part of my campaign...
Anyway, some games that inspired my D&D campaigns are Dragon Age, Baldur's Gate, Mass Effect, Dead Island, Dead Space, Uncharted and Torment. Uncharted was great inspiration for some treasure hunter/pirate style adventures.