I've already heard kvetching to the effect of using Smallville's "soap opera" system for a superhero game. Which is weird to me, since in my experience at their best comics are very similar to soap operas. A game where Spiderman is rolling his "with great power comes great responsiblity" + "gotta hide my secret from Aunt May" vs. Wolverine's "I'm the best asy what I do" + "Gotta keep my mind offa Jean Grey", just inherently sounds awesome.
Though instead of 'values + relationships', something like 'values + melodramatic hook' might be appropriate.