You couldn't do it like it was originally - the anime-influenced vaguely cyberpunk future wouldn't quite work.
But the core theme of the relationship between an aging and bitter Bruce Wayne and a young brash Terry McGinnis would absolutely work. There's a lot of build off of right there.
For me, it would be a hard sell to call something Batman Beyond without the cyberpunk schtick. You could definitely create a new Batman spin off with the same "passing the torch" theme and still get me excited though.