Random comments on the thread:
If you want to play a melee/ranged hybrid, the rogue's your man. Martial power has a lot of encounter ranged attacks for the rogue, and in any case, the ranged backup is an excellent way of ensuring that you get sneak attack as often as possible- you can get a shot in on a far away enemy who has been dazed or otherwise is granting combat advantage.
The podcast didn't exactly address the Twin Strike vs Sure Strike issue. It just addressed whether the +2 attack at wills were worthwhile, in a sort of vacuum. One speaker took pro, one took con. I tend to lean towards thinking that its worthwhile for the Fighter at higher levels- If your epic level basic melee attack hits for 4d6 +7 strength +5 enhancement +4 paragon path bonus Brutal 1, the math starts to shift. The strength is a smaller percentage of your overall damage, so +2 attack starts to be more worthwhile. That doesn't necessarily mean that the at will is a good one, though, since you probably shouldn't have to wait until epic tier to make it worthwhile.
As far as the Ranger is concerned: I personally believe that Prime Shot should be a larger bonus. I think this would go a long way towards making the Archery Ranger more interesting. Lets face it, its an archer, its mostly going to shoot at people. Its also the most damage oriented Striker in the game. And if you're more concerned with damage than with bonus effects, its mostly going to shoot at people with Twin Strike or with upgraded encounter and daily versions fo Twin Strike. You can make this not happen by selecting certain encounter powers, but its not as easy as you might like. In order to make the Archery Ranger fun, you have to be maneuvering around. This 1. gives you something else to do on your turn, and 2. makes it more likely that you'll get yourself into trouble and have to use encounter powers to escape. In order to get you to maneuver more, you need a better incentive to do so. Prime Shot is supposed to provide that incentive, but the bonus doesn't seem big enough to motivate a lot of people.
There are feats which upgrade Prime Shot. I think that taking them is worthwhile, because they might improve your enjoyment of your character. I just kind of wish that Prime Shot was more of a gateway ability- maybe make it so that Twin Strike is unusable unless you are receiving your Prime Shot bonus against at least one of your targets. Rangers would suddenly become the most fast moving, high maneuvering class in the game.
For the record, feats you might want are Called Shot (+5 damage v prime shot target) and Prime Quarry (if target is quarry and prime shot target, +2 attack instead of +1). Both are Paragon, unfortunately.