Hussar
Legend
Spells need line of effect in addition to line of line of sight. It is possible to have one and not the other.
I believe that there are no LOE rules in 5e. Most spells state right in the description that you need to see the target. How about Suggestion then? After all, the target should only need to hear you right?
Or, put it another way. There's a creature with Blindsight on one side of the door. He has never seen beyond that door. Does he know how big the room is beyond the door, presuming the door fits within his range of blindsight?