I ran a MERP/Rolemaster (In ME) game for about 9 years, spanning 2 campaigns. ME certainly rules as far as settings.
I entertained runnign a ME D20 game but with 5 DMed games and 2 more in the works (I seem to be as Mad as the Proverbial Hatter), that would be a bit much.
Well, have fun all
-Uriel