In the past I have had problems with AVG and Spybot not playing well together, (currently I use stopzilla - which is OKay but not spectacular)
I'll just repeat (more or less) what I said in another thread here recently:
I would recommend the stuff I use.

Yeah, big surprise.
This happens to be, for Windows,
Avast! Antivirus,
Malwarebytes Antimalware,
IOBit Security 360 and
Outpost Firewall. They are all freeware, work together flawalessly, are easy to use and (by default) self-configuring, and offer just about everything you'd need for Windows security, other than using Firefox and Thunderbird as browser and email client, and a couple of other minor things. IMO.
Oh, and if you do use an application-level packet-flitering firewall (like Outpost)
make sure you disable Windows Firewall first! Likewise, totally uninstall any antivirus program
before installing any other (like Avast!, for example.)
IOBit 360 Security is particularly handy, whatever else you decide on, because it's that extremely rare (unique?) combination of fast, effective
and real-time (for an anti-malware application, that is.)