The "Days of Future Past" possibility
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Well, there IS another (very interesting) possibility: that this "Realms of the Future" may not come to be - that, in a sense, this is like the "Days of Future Past" storyline form the X-Men comics, the classic "imperfect future", that come to be by actions (or inactions) from the people of the present.
And what this has to be with the Realms? Well, if you read well, you´ll perceive that no Drizzt, no Elminster nor any of the "Great and Powerful" of the Realms were able to stop the coming apocalypse (let´s admit: it IS an apocalypse - how one´s call the decimation of the Sword Coast and the rise of a new Netheril Empire?) - but can´t the actions of the simple PCs CHANGE this dark future?
You see, THIS were always one of the big troubles of the Realms as a setting: your character was a mere witness to the world shaking/world saving actions of the many Chosen of Mystra (and other powerful heroes and villains). But if ONLY the actions of your character can change the world (as we know that EL & Co. wasn´t able to save the Realms).
With that "Drizzt Profecy" you introduce an element of menace and urgency that was lacking ("Save the Realms? Nah, that´s business to Kelben Blackstaff and all this power-houses..."), and shifts the center to the player characters, who must act now on, so the "Dark Realms" don´t come to be - hey, I think I´m going to call my first 4ed Realms character John Connors!
Ok, so it´s only a possiblity, but with Rich Baker saying that they " are not going to overthrow worlds with that much breadth and history", it´s a VERY PLAUSIBLE theory - and one that makes the Realms better too (i.e. this PC-centric point of view is considered one of the strengths fo the Eberron setting).