Are you saying that using high fructose corn (or agave) syrup as your your primary source of sweetener is OK? Because it certainly is NOT.
I am saying that this form of flat statement is not generally true. Whether you can safely use fructose (or any other sweetener) as your primary is entirely dependent on how much sweetener you use.
Feed one person enough HFCS that you clearly see the health problems people fear from HFCS, and feed another person the same number of calories in sucrose, and guess what? That second person will also have health issues! They may be slightly different health issues, but neither is healthy for you in such large amounts. Take those folks who are getting fat on HFCS sweetened sodas and candies, and swap out the HFCS for cane sugar, and they'd still get fat!!!
My point is that fingering HFCS is a dodge. It misses the real issue - people generally eat too many sweets for their activity level. Period. Full stop.