Monster PCs
For humanoids, just use the racial traits from Volo’s Guide to Monsters.
For more exotic monsters, as a rule of thumb, a monster stat block is equivalent to a PC of a level equal to 1.5 × CR, rounded up. However, this can vary on a case-by-case basis, especially for monsters with immunities, spellcasting, or larger sizes.
Calculate your proficiency bonus and hit dice based on your level equivalent. You can swap your skill proficiencies for other skills.
To advance, use the multiclassing rules. You can gain proficiency in one or two of your class saving throws, such that you are proficient in two saving throws (unless you already are).
These rules are experimental; if a monster PC proves un-balanced, we’ll adjust it.