Besides a lot of the ones already mentioned...
The Blues Brothers (first SNL skit to movie, and probably the only good one)
Doctor Detroit
Airplane!
The Howling
Witches of Eastwick
Who Framed Roger Rabbit?
Raising Arizona
Videodrome
Ultimately, though, the 80's will be remembered for introducing the concept of sequelitis, where we take a film that did pretty darn good then proceed to beat the exact same concept to death over four, five, even six parts.