D&D 5E (2024) Representing afflictions in D&D 5e - which do you think work best/least dislike.

[Stormonu]

4e's disease tracks - lots more customisable and was an extensible framework for a lot of different effects

As much as I dislike 4E, this was one of the things I thought was a great idea, and I use something similar for 5E diseases.