It entirely depends on the players. If they are those kind of players who just want to sit together and tell jokes will rolling some dice to kill stuff and afterward tell each other how coolbadassawesome their characters are then go 4E.
If on the other hand they try to explore the game world and like to decide for themselves what to do instead of following a laid out plot railroad and generally have problems ignoring huge inconsistencies like a game world resembling a twisted cuthulu alternate dimension with strange geometry and constantly shifts between battle mode and social mode which operate under very different rules or creatures who are only build for combat and don't have any abilities for things which happens outside combat then play 3E.
You can of course remedy those problems, for example by extensive houseruling and creating (and remembering them to avoid inconsistencies) out of combat abilities for each and every monster you use but that requires so much work that it isn't feasible especially as the result will look a lot like 3E anyway.
If on the other hand they try to explore the game world and like to decide for themselves what to do instead of following a laid out plot railroad and generally have problems ignoring huge inconsistencies like a game world resembling a twisted cuthulu alternate dimension with strange geometry and constantly shifts between battle mode and social mode which operate under very different rules or creatures who are only build for combat and don't have any abilities for things which happens outside combat then play 3E.
You can of course remedy those problems, for example by extensive houseruling and creating (and remembering them to avoid inconsistencies) out of combat abilities for each and every monster you use but that requires so much work that it isn't feasible especially as the result will look a lot like 3E anyway.