I didn't see anyone mentioning Fading Suns, yet. It's a very enjoyable (very) far-future space-opera setting that gives a nice Dune-esque feeling.
So from what I can tell, these would be the 4 books I would need to run the game?
The D6 System: The Customizable Roleplaying Game (1996)
D6 Space
D6 Space: Aliens I
D6 Space: Ships
Thanks for the link.
Thanks for all the suggestions. There is more out there to choose from than I realized. One question for TreChriron. I couldn't find anything on Dust. Anyone have a link to that?
Still haven't made a decision yet. Haven't even had a chance to get through all the suggestions. Really appreciate all the advice though.