I loved the movie, but one thing did occur to me:
What's up with the University that Peter Parker attend? It's like the metahuman generator.
1) Pete gets bit at the science lab and becomes Spider Man.
2) Doctor Octopus was apparently associated with the University at one time (Prof. Connors knows him anyway).
3) Prof. Connors will some day become the Lizard.
4) I wouldn't be suprised to find out that Oscorp funded a lot of research at the University.
Also, a common theme from the comic book that carries over to the movie: Being associated with Peter Parker leads to insanity and the development of superpowers.

1) His best friends' father. (Green Goblin)
2) One of his scientist heroes becomes a supervillian shortly after meeting him. (Doc Ock)
3) His best friend. (Hobgoblin)
4) His teacher at the university (Prof. Connor - The Lizard)5) A fellow employee at the Daily Bugle (Eddie Brock - Venom)
I know it's to make the conflicts more personal to Peter Parker, but you think people would notice a trend after awhile and start avoiding him (or seeking him out).