Most superheroes have villains that fit their theme. The X-Men deal with mutants and mutant-hunters, the FF deal with big monsters, rival geniuses, and aliens, and Spider-Man deals with science freaks.I would vote Lizard, but for one issue. So far, every main* villain we've seen in a Spiderman movie has been the result of a scientific accident. I'd like to see them go a different route at least once before returning to that method.
Take a look at Spider-Man's rogue's gallery:
- Green Goblin and variants (e.g. Hobgoblin)
- Venom and variants (e.g. Carnage)
- Doctor Octopus
- Electro
- Kingpin (not science-based, but unavailable for the movies)
- Kraven the Hunter (not science-based)
- Lizard
- Mysterio (tech-based)
- Sandman
- Scorpion (science and tech)
- Vulture (tech)