For my money, it's Advanced Sagebrush & Shootouts.
Production values are high. The hosts have good mics and don't eat food into them.
Episodes are edited down to just the listenable parts, which are 20-30 minutes long and don't require a 2-hour commitment.
Each episode is bookended with a little sketch about a Narrator character.
After each arc, there are bonus songs about things that happened, as well as a tabletalk reviewing the arc.
The jokes the hosts make aren't just quoting memes.
The setting of a modern day Buddy Cop show is unique among a sea of generic DnD podcasts.