Coming from personal experience as the person who developed NPC Designer, an npc generator for 3.5. I think it would depend more on what part of the game you were trying to replace the human interaction with computer interaction. Mark CMG and I basically use computers the same with regard to how we handle gaming, they are used to make my job as a DM easier. Since I never changed to 4e, I have had quite a few years to develop software specifically to resolving different challenges I wanted to shift over to the computer. I couldn't imagine not having a computer to prep for or run a game these days.
Personally speaking my goal is not for a computer to be able to replace a DM but rather be able to create quality content for a DM to use.
Personally speaking my goal is not for a computer to be able to replace a DM but rather be able to create quality content for a DM to use.