The main difference is that TWD goes from beginning to middle and/or end of the zombie apocalypse. TLOU skips right to the middle/end of it. Both use the zombies/fungal infected as a back drop and focus mainly on the characters and their stories. TLOU just gets right down to it and isnt nearly as repetitive in its story telling as TWD.It will be interesting to see how (or if) it differentiates itself apart from the fungus origins of the zombies. I wonder if the different mediums of their sources will make any kind of difference? I'm honestly not sure!