As someone who is currently running a homebrew setting in PF2e (with VERY different assumptions that Golarion(?)), I'll have to disagree with this. While I'm impressed with their (Paizo's) setting it is NOT easy to scrub from the ruleset.Yeap, gotta second this. Paizo did it right again. For the sake of homebrewers who wont care about settings at all, you want an easily scrubbed default.
I'm happiest with an implied setting. Especially with a ruleset as crunchy/elaborate/detailed as DnD and its derivatives.
Paizo's is NOT an implied setting. It channels you very heavily into Golarion, and its adventure paths, and even its organized play. And while I understand the business reasons behind their decision, it can be awkward for me to work with and around.