1) Don't bring a lot of RL current American politics into it. Being an X in a Y colored state, that gets old
fast.
1b) Whatever political issues you bring into the mix, make sure that the waters are muddy enough that it's not a clear "This is the right choice"/"This is the wrong choice". It's best when no one on the proverbial playing field is squeaky clean or obviously In The Right.
2) You better find some decent social skill rules. Just "Sense motive vs bluff" "Diplomacy and Intimidate vs Level check" is... very very limiting. Also be aware that there are no hard and fast rules for roleplaying encounter CRs. What's the CR of convincing a Baron to stop an execution? Convince a king to stop or start a war? By the rules, it's "His level or CR", but if the Baron is a Baron because his father was a Baron, rather than being a 10th level aristocrat, then stopping them from killing the innocent man may not be worth the XP.
3) As others have said, decide what classes are appropriate, and how much action is going to be in it. Also,
make sure the PCs are into it. Lots of manipulation of NPCs and juggling favor is exciting for some, but others are just not apt at the social gymnastics and mental planning.
4) If you have a mixed group, try to throw elements of all of it into a pot and pray for the best.