In answer to the original question: Go with Eberron. It's fresh, it's fun, it takes old things and makes them seem new. And it's coherent within itself - the world was designed as a whole, instead of piecemeal, which gives it a very different feeling. Forgotten Realms was the setting that got me into D&D (thanks, Baldur's Gate!) but it's very Tolkien-meets-historical-Earth. Except with lots of elves. And plenty of very powerful NPCs. And quite a few gods. And...
Well, I could go on. I do still like Forgotten Realms, but Eberron's my setting of choice.
Demiurge out.