Problems with lance
In any fantasy series, every author/game master/player wants their characters to be the heroes. Heroes change things. The problem with DL is that there are about 12 heroes total, almost all the books have something to do with them, and there is no other room for any other heroes to change the world. Its already blown up from the passing of the last ones.
The DL Chronicles was a great series of books, had a great plot and occured in an ok world. But with a single campaign like that which dominates the entire world (and the same characters in sooo many books), a standard PC group will always be overshadowed by the actions of those heroes. A gamer's piddly little adventuring party will never be as cool as the people who put together the lance and saved the world. If they are as cool, we would be talking about having near catyclismic events in just about every campaign.
Realms is similar, but not as bad because there is still a lot to do. While a party is likely to get overshadowed by Cyric and Kelemvor, those gods are only 2 of a HUGE list, and the books they came from can be seen as just "the way those people became gods" as opposed to the DL problem of "This is the greatest threat to hit the world since the catyclism, this is how it was defeated, and now everything you little adventurers will do afterwords will suck so bad that you might as well not even play."
This became more of a rant than I was expecting but I hope it explains my primary problem of the world. The books were great, but too earth shattering. Maybe a game that occured 10,000 years before or after the events of most DL products would be more fun because it would be an open door to make any adventuring party save the world for themselves.
ps: this is also why I hate Elminster, but dont get me started.