Sure. But again it feels like excuses to not try and hide behind the fear of complexity rather than remember that D&D fans are often fans of regions and paradigms of places of fiction or real life areas just as complex.
I mean D&D fans understand the Pantheons of their favorite settings.
What if each deity was associated with a nation? And some deities were patrons and creators of certain species? Or they favored a certain class? Are you an orc from Gruumsh City or the LG god some orcs left to worship? Is your species' patron deity dead or disappeared and your people under an adopted God (tiefling);or split between many (Goliaths and humans)? Is Fort Artemis just where the world's rangers go to get trained?
A little flavor and most people can get it?