| Mythic Odysseys of Theros | 
| Setting | Notes | 
|---|---|
| Avernus | Layer of Hell; no setting book, but covered in Baldur's Gate: Descent into Avernus adventure | 
| Eberron* | Eberron: Rising from the Last War; pulp and fantasy technology | 
| Forgotten Realms | Generic fantasy; a partial setting book (Sword Coast Adventurer's Guide); the default setting for most official D&D adventures which often contain additional setting information | 
| Greyhawk | No setting book, but the setting used in Ghosts of Saltmarsh | 
| Ravenloft* | Gothic horror; Van Richten's Guide to Ravenloft, also partially covered in Curse of Strahd adventure | 
| Ravnica* | Guildmaster's Guide to Ravnica; MtG setting of a giant city | 
| Spelljammer* | Spelljammer: Adventures in Space, Astral spaceships | 
| Strixhaven* | Strixhaven: A Curriculum of Chaos, MTG setting in a wizard school | 
| Theros* | Mythic Odysseys of Theros; Greek-themed MtG setting | 
| Wildemount* | Explorer's Guide to Wildemount; the Critical Role setting | 
| Setting | Notes | 
|---|---|
| Amonkhet | Egyptian-inspired | 
| Dominaria | Default MtG setting | 
| Innistrad | Gothic horror-themed, vampires, werewolves | 
| Ixalan | Mesoamerican-inspired; Sun Empire, dinosaurs | 
| Kaladesh | Clockwork, airships, artifice | 
| Zendikar | Adventure world of ancient ruins | 
| Game | Publisher | Notes | 
|---|---|---|
| Advent Horizon | Promethium Books | Semi-hard science fiction, plus eldritch horrors | 
| Adventures in Middle Earth | Free League | Tolkien | 
| Affinity - Conestoga | Dias Ex Machina Games | Adventures of giant adrift alien spaceship, part of Affinity trilogy of interconnected settings (see below) | 
| Affinity - Paradise | Dias Ex Machina Games | Weird magitech fantasy in an orrery star system, incorporates Ultramodern5 rule changes, also see above | 
| Affinity - Torus | Dias Ex Machina Games | Art-Deco Weird West, also, see above | 
| Amazing Adventures | Troll Lord Games | Multi-genre, modern, pulp, scifi | 
| Anime 5e | Dyskami Publishing | Another supers in 5e. In truth it just imports large parts of M&M 2e into 5e. | 
| Beast World | Heartleaf Games | Furry adventure | 
| Beowulf: Age of Heroes | Handiwork Games | Norse fantasy, rules reworked for 1 DM + 1 player | 
| Black Iron | Feral Gamers Inc | Grimdark S&S | 
| Bloodlines & Black Magic | Storm Bunny Studios | Modern Occult | 
| Capes and Crooks | Crit Academy | Superheroes | 
| Carbon 2185 | Dragon Turtle Games | Cyberpunk | 
| Dark Matter | Mage Hand Press | Science fiction, plus mega-damage in 5e! | 
| Dark Souls: The Roleplaying Game | Steamforged Games Ltd | Dark Souls: The Roleplaying Game, duh | 
| DarkEnergy | Entanglement Interactive | Magic postapocalypse, RIFTS-ish | 
| Deathbringer RPG | OSR hack from Youtuber Professor Dungeon Master | |
| Demiverse | Gnome Mage Games | The multiverse exploded and the dimensions smooshed back together, wrong. Lots of extra planes to add to your game | 
| Doctors and Daleks | Cubicle 7 | Doctor Who 5e | 
| Entromancy | Nightpath Publishing | Cyberpunk, Shadowrun-style fantasy | 
| Esper Genesis | Alligator Alley Entertainment | Sci-fi, Mass Effect-like | 
| Fateforge | Studio Agate | French sword & sorcery | 
| Five Torches Deep | Sigil Stone Publishing | OSR hack of 5e | 
| Gaslight Victorian Fantasy | Battlefield Press International | Victorian Fantasy | 
| Genefunk 2090 | CRISPR Monkey Studios | Cyberpunk, focus on biotech | 
| Ghost Ops Second Strike | FeralGamersInc | Tom Clancy tactical spec ops | 
| Hereafter | Sigil Entertainment | Bad news, you're dead! Enjoy the afterlife, but you may be able to escape back to the living world | 
| Hellboy | MANTIC | Comic-book | 
| Kisarta | Sushi Role | You're dead, and afterlife is terrible. Yep, somehow you're damned and the beings in charge are not nice. But there seems to be plenty to do though. | 
| Level Up: Advanced 5th Edition | EN Publishing | Reworking of 5e rules from the ground up | 
| Lost Lights | Side Quest Press | Persian setting plus mythology | 
| Olde Swords Reign | Fumble Table | OSR hack of 5e | 
| Path of the Planebreaker | Monte Cook Games | Moon sized object plummets through dimensions collecting items, and people; bringing doom as it goes | 
| Pugmire / Mau / Squeaks in the Deep | Onyx Path Publishing | Uplifted dogs, cats, birds, reptiles & rodents in post-human Earth | 
| Ruin 5th ed, The | FeralGamersInc | Realistic postapocalypse | 
| S5E | Sigil Entertainment | Brings at-will powers to the fore allowing incredibly powerful characters | 
| Spy Game, the | Black Cats Gaming | Espionage | 
| Stargate | Wyvern Gaming | Sci-fi | 
| Tales of Arcana | Arcanomicon LLC | Hundreds of races, plus setting tied together to create a 5e Wold Newton type setting. Also really funny in places. Allows players to be puppets, transformers etc! | 
| The Sundering | UH Studios | Gods fell from the skies, continent sized flaming blades sheared the nations. Has Crystal Spheres and Spelljammer compatible! | 
| Tomb of the Colossus Gods | Lion Banner Games | Campaign plus adventure. They even invented their own language. There's verisimilitude for you. | 
| Ultramodern5 | Dias Ex Machina | Modern | 
| Whispers in the Dark | Saturday Morning Scenarios | Call of Cthulhu, 5E style, 1870s New Orleans | 
| Liberty: AFTER | John Dossinger Publishing | Sci-fi, post-apocalyptic | 
| Setting | Publisher | Notes | 
|---|---|---|
| Acheron | Ulraunt's Guide to the Planes | Outer Planes, war-torn battlefields | 
| Infinite Staircase | Oliver Darkshire | Use the Infinite Staircase to travel the planes | 
| Rites of the Infinity Guard | Aripockily | Become a protector of time, and banish those that would disrupt it | 
| Shadowfel | Ulraunt's Guide to the Planes | Outer Planes, horror | 
| Traveler's Guide to the Cosmos | Aripockily | Bring the cosmos to your doorstep and travel the universe | 
| Setting | Publisher | Notes | |||
|---|---|---|---|---|---|
| 2099 Wasteland | Legendary Games | Post-apocalyptic | |||
| Adventurer's Guide to the Bible | Red Panda Publishing | You'll never guess it... | |||
| Aetaltis | Mechanical Muse | Classic Fantasy | |||
| Agents of G.A.I.A. | Battlefield Press International | Modern Urban Fantasy | |||
| Aihrde | Troll Lord Games | Fantasy | |||
| Alessia | Storm Bunny Studios | Wuxia science fiction fantasy | |||
| Alfeimur | L&A Media | Dark sword and sorcery | |||
| Aigyptos | Skirmisher Publishing | Egyptian | |||
| Amethyst: Quintessence | Dias Ex Machina Games | Science vs. magic | |||
| Arcana of the Ancients | 5e release of Numenera setting | ||||
| Ancient Adventures | Mal & Tal Enterprises | Ancient Greece | |||
| Arcanis | Paradigm Concepts | Roman | |||
| Arkadia | Arcana Games | Greek | |||
| Arora | Ghostfire Gaming | Post-dragon apocalypse | |||
| Aquilae | Infinium Game Studio | Setting of Dark Obelisk adventures | |||
| Auroborous: Coils of the Serpent | Warchief Gaming | Epic fantasy | |||
| Blood & Bone | Arcana Games | Grimdark, no magic | |||
| Blue Rose | Green Ronin | Romantic Fantasy | |||
| Book of Exalted Darkness | Legendary Games | Decopunk good and evil | |||
| Brancalonia | Acheron Books | Spaghetti Fantasy | |||
| Burning Skies | EN Publishing | High fantasy, war, setting of War of the Burning Sky | |||
| Cloak & Coin | Red Turban Press | Mercenary fantasy | |||
| Churn Campaign Setting, The | Thomas Fuentes | TBD (typical fantasy?) | |||
| Comets & Cockpits: Geographica Adelphos | Daylight Publications | Junker Space Fantasy! (Star Wars meets Mad Max) | |||
| Dark Matter | Mage Hand Press | Sci-fi | |||
| Dragon Heresy | Gaming Ballistic, LLC | Norse | |||
| Ebonclad | Dan Coleman Productions | Thieves' guilds | |||
| Eldritch Sands | Poison Potion Press | Magitech Destiny/Warframe-like | |||
| Embers of the Forgotten Kingdom | Metal Weave Games | Soulslike | |||
| Ethereal Expanse | Ghostfire Gaming | Astral pirates and seafaring | |||
| Fading Embers | Valiant Fox Gaming | Magical Ice Age | |||
| Farland, World of | S. Baker | World ruled by evil | |||
| Grim Hollow | Ghostfire Gaming | grimdark fantasy | |||
| Gullet Cove | Steamforged Games | Cats and dogs | |||
| Hellenistika | Handiwork Games | Greek | |||
| HELLSCAPES | Scrivened, LLC | Postapocalyptic Toolkit | |||
| Hereva | Xacur | Witches | |||
| Historia | Mana Project Studio | Dark Fantasy Renaissance Talking Animals | |||
| Historica Arcanum: City of Crescent | Metis Media | 19th Century Ottoman Urban Fantasy | |||
| Humblewood | Hit Point Press | Birdfolk and other animals | |||
| Hypercorps 2099 | Legendary Games | Cyberpunk superheroes | |||
| HYPERLANES | Scrivened, LLC | Scifi toolkit | |||
| Inferno | Acheron Books | Based off of Dante's Divine Comedy | |||
| Iskløft | Skald Publishing | Vikings | |||
| Iron Kingdoms Requiem | Privateer Press | Steampunk Age & Magitech Mechas | |||
| Journey to Ragnarok | Mana Project Studio | Norse | |||
| Koryo Hall of Adventures | Red Scales Publishing | Korean fantasy | |||
| Land of Myth | Seven Thebes | Greek | |||
| Lasers & Liches | 
 | Retrowave aesthetic | |||
| Legendary Planet | Legendary Games | Science Fantasy AP | |||
| Legendlore | Onyx Path | Isekai D&D, based on comics | |||
| The Lost Lands | Frog God Games | Collection of settings, high fantasy inspired by various cultures | |||
| Lost Lights Campaign Setting | Side Quest Press | 2 continents affected by the aftermath of a celestial war | |||
| Manastorm | Terran Empire Publishing | high fantasy | |||
| Midgard | Kobold Press | European dark fantasy | |||
| Midnight - Legacy of Darkness | EDGE Studio | Fight back in world where Not-Sauron has won in Not-Middleearth | |||
| Mists of Akuma | Storm Bunny Studios | Eastern fantasy noir steampunk | |||
| Monsters of Murka | Action Fiction | Political satire | |||
| Neurospasta | Dias Ex Machina Games | Cyberpunk transhuman | |||
| Nightfell | Mana Project Studios | Horror fantasy | |||
| Odyssey of the Dragonlords | Arcanum Worlds | Greek | |||
| Planegea | Atlas Press | Prehistoric D&D | |||
| Ponyfinder | Silver Games LLC | Talking Animals | |||
| Primeval Thule | Sasquatch Game Studio | Sword & Sorcery | |||
| Ptolus | Monte Cook Games | City-based Fantasy | |||
| Pure Steam | ICOSA Entertainment | Steampunk | |||
| Red Opera | Apotheosis Studios | heavy metal | |||
| Retroverse | Lasers & Liches | Setting for Lasers & Liches | |||
| Rocket Age | Why Not Games | pulpy retro-scifi | |||
| Ruins of Symbaroum | Dark fantasy | ||||
| Runewild | Sneak Attack Press | Dark Fairy Tale Forest | |||
| Savage Company | SHM Publishing | Goblins/Orcs/etc with guns | |||
| Scarred Lands | Onyx Path Publishing | Greek-inspired | |||
| Seas of Vodari | Tribality Publishing | Swashbuckling nautical | |||
| Sherwood: The Legend of Robin Hood | Battlefield Press International | Swashbuckling Historical | |||
| Snowhaven | High Level Games | Snowpunk | |||
| Spaceships and Starwyrms | HopePunk Games | Scifi toolkit | |||
| Supers & Sorcery | Daylight Publications | Superhero | |||
| Svilland | Dream Realm Storytellers | Norse | |||
| Tails of the City | Silver Games LLC | Talking animals | |||
| Tal'Dorei | Green Ronin | Critical Role's setting | |||
| Talislanta: the Savage Land | Nocturnal Media | Fantasy dark ages, 5e version of classic setting | |||
| Theria | Dungeons & Randomness | low-magic shades of grey | |||
| Thrones & Bones: Norrøngard | Lazy Wolf Studios | Based on novels of Lou Anders, north horror fantasy | |||
| Vast Kaviya | Legendary Games | Primordial sword and sorcery | |||
| Wardlings | Renegade Game Studios | Child Heroes | |||
| World of Myrr | Cawood Publishing | Heroic fantasy | |||
| World of Nimbus, The | Bronze age sword & sorcery | ||||
| World of Xoth | Xoth.Net Publishing | Sword and sorcery | |||
| Zeitgeist | EN Publishing | Renaissance |