i don't think the main quest can time out but some of the character ones can but there are trigger points, I suspect. That is, either the timer kicks off when the quest is received, or you when you reach some milestone.Wait what? Quests can time out? That ratchets up my anxiety.
Like the Druids are ready to flee at any moment! But I have to wait a couple levels to deal with the Goblins..... and Im looking for Karlach...