I was about to say the same thing. There is so much support for MSH, that I don't think there are any characters that you couldn't do in the system. Heck, the entire Marvel universe circa the 1980s has been officially statted up using the system.
Personally, I find the d20 holdovers in M&M to be a detriment. The separation between stats, secondary stats like attack rolls, skills, and feats/advantages (and then M&M-specific equipment and powers) allows for a lot of customization, but a lot of it is pointless, IMO. I can say, "I want to build a martial artist" (for example) and I see all the different levers that could be moved to achieve similar results at different costs, and it just looks needlessly complicated to me. Do I want the Fighting stat? Close Combat skill? The Close Attack advantage? Some mix? In what proportions? And that just covers my attack bonus - I haven't even gotten to any cool superhero-type stuff yet.
As a result of stuff like that, I've become more a fan of "looser," more narrative systems that don't sweat the small stuff and work more like comic books read. I really like the last Marvel RPG, although it sadly got discontinued when Marvel yanked the license for unknown reasons.