I think at least since I got my hands on the buggy ToEE, if not before, I have associated Atari with "suck". I wouldn't shed a tear if they lost the D&D brand name.
I may not be one for playing 4E at the game table, but I'd like to see a decent 4E video game, especially one that could mix real-time and turn-based (real-time in town or during travel, turn-based in combat - like ToEE, but without the crashing bugs)*. I think it'd be a real hoot if there were, say, a task bar along the bottom with the different "powers", mousing over expanded it to look like the 4E power cards and clicking it "slapped it down" into play and you'd then watch the animation of the power play out, selecting target and any other info as it moved down the "card".
As to a 4E FR game bombing because the realms changed - I don't think so, if the engine is done right. Or were all previous versions of Fallout set in the Washingon, D.C. area? Perhaps in D&D, we might see a return to Phlan?
* Heck, this afternoon I was playing Sid Meier's Pirates - the combat for taking over a city in this game is a gridded, turn-based combat and was put out in 2004. Also, there's still people playing souped-up hi-res versions of turn-based Nethack as recent as 2003 that I just looked up.