I live in a rural hole in northcentral Illinois, although it's the largest county, it has the smallest population per square mile of anywhere in Illinois, which means there are only so many players available. Most local gaming groups are very insular - unless new players are friends with existing ones, we don't get too many new players to our table, let alone to our knowledge. Me, I've got experience playing a dozen or more different gaming systems (most of the non-D&D systems were played in the 1980's). Recently I even downloaded the Campaign Guide and Players Options for Santiago, however, I already know for certain that my players only play D&D/Pathfinder, and they only want to play in a standard fantasy environment. Other than the one shots, I can't even get my players to play in my own published setting - Kaidan the setting of Japanese horror. So I can expect that they won't want to play in the world of Santiago either. The older players are stuck in their preferred mindset of standard fantasy, while the younger players lack the initiative to want to try anything else.
I like a variety of types and genres of RPG gaming and my players do not. So its standard D&D/Pathfinder for my table, whether I like that or not.
And as stated, due to the lack of RPG gamers in general, it's not probable to find another group easily, and even then, other groups are just as insular as ours, and I'm likely to run into the same problem. I know of one other group that only play GURPS or their DMs private designed game which is a lot like GURPS.
So that's my situation. Also I don't care to play online using VT apps, so that's not a solution for me either.