I have culled from the collection periodically, but tried to stop doing it because I usually end up missing some of what I get rid of later on. Generally, when I have moved I try to slim the collection down, sometimes I look at the shelves and feel bad for all the books I don't have time for, but in recent years I have gotten into a habit of trying to focus on the parts of my collection I have the most genuine interest in, and cut out as much of the "Oooh I might find this useful one day" purchases that can clog it all up. (I have had mixed results in this effort).
I have spent a lot of money recently trying to rebuild some parts of my collection I got rid of a long time ago (I have sunk a nontrivial fortune into recollecting 3rd edition D&D books, for example, despite being convince back in the 4E/Pathfinder 1E days that I would never return or look back). Turns out I was wrong, and D&D 3/3.5 is sitting in my sweet spot for nostalgia right now, even though I never thought that would happen. So.....that's my only warning, be careful what you get rid of!