Yes! E6 works perfectly fine with Pathfinder. In fact I'd say it works better than 3.5 because there are no "dead levels" in Pathfinder as there were in 3.5, so every level every class will get something new.
E6 is mainly a framework to build a campaign around, so the big issue is the GM figuring out what "epic" level feats are going to be available for characters that go beyond 6th level.
I was running an E6 campaign for awhile that was going well. The only reason it went on hiatus had to do with real life getting in the way. You can check out what we had going here.
E6 is mainly a framework to build a campaign around, so the big issue is the GM figuring out what "epic" level feats are going to be available for characters that go beyond 6th level.
I was running an E6 campaign for awhile that was going well. The only reason it went on hiatus had to do with real life getting in the way. You can check out what we had going here.