The old LCD e-readers were a pain in the eyes, but not with e-ink, no. Looks just like a book, only no color yet. I love the look and feel of a book, but I saw one of those demos in a Barnes and Noble and I'm a convert.eyeache?
I am thinking my next laptop will actually be a tablet.
...I've been following the development of the QUE proReader from Plastic Logic:
QUE proReader
Check out the PDF in the Press Kit for more info.