freyar
Extradimensional Explorer
They don't.
Well, to first-order approximation they don't - they are electromagnetic waves, and so they like to interact with electric charges, even when they themselves are neutral. There are some more rare effects that make for a non-zero probability of it happening.
But either way - when a particle-antiparticle pair interact, they turn to energy, which likely comes out as photons that had energy that totaled up what went into the particle-antiparticle pair.
When the photon-antiphoton pair interact, they turn to energy, which likely comes out as... photons. Photons with the same total energy as what went in. So... they'd look *exactly the same*. How would you really know if they'd interacted or not?
Freyar will likely grump at me now for being a tad inexact. I'll deal![]()
Nah, this is all good.

One is that two photons can interact and turn into an electron/anti-electron pair if they have enough energy to do so. If you had an easy way to make very energetic photons, this would happen as much as electron/anti-electron annihilation. People usually call it pair creation from the electron's point of view. These events are rare not because they are unlikely to happen given the right circumstances but because we don't really have too many ways to make lots of high energy photons, at least not without using some kind of matter/anti-matter annihilation to start with (so the right circumstances are rare).
The other type of rare event is photons actually bouncing off of each other. At a microscopic level, the photons don't interact with each other but with quantum "virtual" electrons. This is a rare event just because, even when photons get close to each other, they don't generally both interact with virtual electrons at the same time.