Wait a minute, didn't all these changes already happen with that Times of Troubles-sillyness already? All Assassins died back then, gods died in the dozens, new nations arised, the changes from a totally hog-wash medieval fantasy world to a even more hog-wash renaissance world, floating islands, tons of portals and all that stuff... Also, in 3rd edition, Faerun never was part of the Great Wheel anymore, it was ret-coned to be always these crystal-sphere-thingies in the official campaign book.
Of course, the Forgotten Realms always were hog-wash, and trying to make all these things stick to canon makes it like Star Trek. As soon as there is some change, or something doesn't stick to canon, it's the ultimate terror, and the sky is falling. I'd rather have new iterations, like Transformers: Animated retelling the Transformers saga, but this time even better.