Started with 2E (basically at the 1E/2E transition, most people I knew were playing 1E), played the hell out of it, played 2.5E for a while (even after 3E came out), played 3E, mostly skipped 3.5E until a year or so ago.
I'm strongly inclined to switch to 4E. It has cons, more and more significant cons than 3E had, even, but it also has a lot more "pros" for me than 3E did, and it slaughtered a lot of sacred cows I was keen to see go.