I've bought Corvus Belli Infinity, Star Trek Adventures and Dishonored. I've never gotten any of them to the table and haven't bought the equivalent VTT ruleset to run a campaign online - only STA is available for the Fantasy Grounds VTT I use. So I chose the poll option of "I've never played it."
Of those I own, STA has impressed me the most. While Dishonored seems to capture it's setting well, it also seems to add some complexity to the core to do it. It's admittedly the 2d20 setting I've read the least, so my impression might be wrong. The STA book has impressed me enough to want to run a STA campaign, but I don't have enough local players that are keen for it. I could see myself eventually buying the VTT ruleset to run games online, but STA games are rare in the Looking for Group/Players forum for my VTT and I'd need some real-time gameplay before making the leap. A GM has recently advertised a 2d20 Dune campaign though.
I'm more of a homebrewer than anything, so I bought CBI because when I made a query on another forum as to which 2d20 game is most supportive of homebrewing, it was recommended. While it's true you could homebrew a Sci-Fi campaign with it, IMO it isn't suited to brewing anything outside that genre - at least not without a lot of heavy lifting. Not a big deal because Sci-Fi is one of my favorite genres, but I already can and have homebrewed that with Traveller, Savage Worlds+Sci-Fi Companion, The Cepheus Engine, FATE Core and my old but beloved True20+Handbooks. So CBI sits in a crowded space among the Sci-Fi RPGs I own and I've yet to use it. It doesn't help that some of its homebrewing tools are quite weak. CBI is the 2d20 book I've spent the most time reading, but the one that's impressed me the least.
I will say that the 2d20 settings I own have struck me as rules that would make sense once it was at the table and the dice started rolling.